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Effect of Dietary Zinc Methionine Supplementation on Growth Performance, Immune Function and Intestinal Health of Cherry Valley Ducks Challenged With Avian Pathogenic Escherichia coli

文献类型: 外文期刊

作者: Chang, Yaqi 1 ; Mei, Jia 1 ; Yang, Ting 1 ; Zhang, Zhenyu 1 ; Liu, Guangmang 1 ; Zhao, Hua 1 ; Chen, Xiaoling 1 ; Tian, Gang 1 ; Cai, Jingyi 1 ; Wu, Bing 4 ; Wu, Fali 1 ; Jia, Gang 1 ;

作者机构: 1.Sichuan Agr Univ, Inst Anim Nutr, Key Lab Anim Dis Resistance Nutr China, Minist Educ, Chengdu, Peoples R China

2.Jiangxi Acad Agr Sci, Inst Anim Husb & Vet Sci, Nanchang, Peoples R China

3.Meishan Vocat Tech Coll, Inst Anim Husb & Vet Med, Meishan, Peoples R China

4.Chelota Grp, Guanghan, Peoples R China

关键词: zinc methionine; avian pathogenic Escherichia coli (APEC); growth performance; intestinal immune; meat ducks

期刊名称:FRONTIERS IN MICROBIOLOGY ( 影响因子:6.064; 五年影响因子:6.843 )

ISSN:

年卷期: 2022 年 13 卷

页码:

收录情况: SCI

摘要: This study was carried out to evaluate the effects of supplemental zinc methionine (Zn-Met) on growth performance, immune function, and intestinal health of meat ducks challenged with avian pathogenic Escherichia coli (APEC). A total of 480 1-day-old Cherry Valley male ducks were randomly assigned to 8 treatments with 10 replicates, each replicate containing 10 ducks. A 4 x 2 factor design was used with four dietary zinc levels (0, 30, 60, 120 mg Zn/kg in the form Zn-Met was added to the corn-soybean basal diet) and challenged with or without APEC at 8-days-old ducks. The trial lasted for 14 days. The results showed that a dietary Zn-Met supplementation significantly increased body weight (BW) of 14 days and BW gain, and decreased mortality during 7-14-days-old ducks (p < 0.05). Furthermore, dietary 30, 60, 120 mg/kg Zn-Met supplementation noticeably increased the thymus index at 2 days post-infection (2 DPI) and 8 DPI (p < 0.05), and 120 mg/kg Zn-Met enhanced the serum IgA at 2 DPI and IgA, IgG, IgM, C3 at 8 DPI (p < 0.05). In addition, dietary 120 mg/kg Zn-Met supplementation dramatically increased villus height and villus height/crypt depth (V/C) of jejunum at 2 DPI and 8 DPI (p < 0.05). The TNF-alpha and IFN-gamma mRNA expression were downregulated after supplemented with 120 mg/kg Zn-Met in jejunum at 8 DPI (p < 0.05). Moreover, dietary 120 mg/kg Zn-Met supplementation stimulated ZO-3, OCLN mRNA expression at 2 DPI and ZO-2 mRNA expression in jejunum at 8 DPI (p < 0.05), and improved the MUC2 concentration in jejunum at 2 DPI and 8 DPI (p < 0.05). At the same time, the cecal Bifidobacterium and Lactobacillus counts were increased (p < 0.05), and Escherichia coli counts were decreased (p < 0.05) after supplemented with Zn-Met. In conclusion, inclusion of 120 mg/kg Zn-Met minimizes the adverse effects of APEC challenge on meat ducks by improving growth performance and enhancing immune function and intestinal health.

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