文献类型： 外文期刊
作者： Wang, Xumei 1 ; Wang, Hui 1 ; Ye, Yunhua 2 ; Yang, Ping 1 ; Liu, Guangxian 4 ; Hu, Yueming 1 ; Tu, Zongcai 1 ;
作者机构： 1.Nanchang Univ, State Key Lab Food Sci & Technol, 235 East Nanjing Rd, Nanchang 330047, Jiangxi, Peoples R China
2.Jiangxi Normal Univ, Natl R&D Branch, Ctr Convent Freshwater Fish Proc, Nanchang, Jiangxi, Peoples R China
3.Jiangxi Normal Univ, Engn Res Ctr Freshwater Fish High Value Utilizat, Nanchang, Jiangxi, Peoples R China
4.Jiangxi Acad Agr Sci, Inst Food Sci & Technol, Nanchang, Jiangxi, Peoples R China
关键词： ultrasound-assisted glycation; alpha-lactalbumin; allergenicity; intestinal microflora; BALB/c mouse model
期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.125； 五年影响因子：4.096 ）
ISSN： 0022-5142
年卷期：
页码：
收录情况： SCI
摘要： BACKGROUND: Ultrasound-assisted glycation is a promising method for decreasing the allergenicity of alpha-lactalbumin (ALA). However, there is a lack of in vivo studies on the allergenicity of ultrasound-assisted glycated ALA. In this study, the effects of the ultrasound-assisted glycation of ALA on the allergenicity and intestinal microflora were characterized using a BALB/c mouse model. RESULTS: Increased immunoglobulin -G/ immunoglobulin-E (IgG/IgE) and interleukin-4/6 (IL-4/6) secretions, and reduced interferon-gamma (IFN-gamma) secretions were found in the serum of ALA sensitized and challenged, mice in comparison with a control group. However, there was no significant difference between the mice fed with ultrasound-assisted glycated ALA and the control group. Mice that were sensitized and challenged with ALA showed disrupted intestinal microflora, manifesting in significantly decreased Firmicutes and significantly increased Proteobacteria. It was found that 100ALA-gal could maintain the intestinal microflora of mice in a normal state. Pearson's rank correlation showed that Proteobacteria and Spirochaetota were correlated positively with the IL-4/IL-6 level and were correlated negatively with the expression of IFN-gamma. Proteobacteria were also significantly positively correlated with IL-6 and negatively correlated with IFN-gamma (P < 0.05). CONCLUSION: These results suggested that ultrasound-assisted glycation on ALA can maintain the intestinal microflora in a normal state thus balancing the proportion of Th1/Th2 to decrease allergic reaction. (C) 2022 Society of Chemical Industry.
- 相关文献
作者其他论文 更多>>
-
Insight into the molecular mechanism underlying the enhancement of antioxidant activity in ovalbumin by high-energy electron beam irradiation
作者：Chen, Haiqi;Bian, Zhongyue;Wen, Pingwei;Wang, Hui;Hu, Yueming;Tu, Zongcai;Hu, Yueming;Tu, Zongcai;Liu, Guangxian;Hu, Yueming;Wang, Hui;Liu, Guangxian
关键词：Ovalbumin; Antioxidant activity; Irradiation; Oxidation sites; Mass spectrometry
-
Fermentation of asparagus juice using selected probiotic Lactiplantibacillus plantarum JGS49 isolated from pickled asparagus: microbiological, physicochemical and flavour characteristics
作者：Huang, Jinqing;Wang, Li;Li, Xue;Zhang, Yao;Yuan, Linfeng;Liu, Guangxian;Huang, Jinqing;Du, Tonghao;Xiong, Shijin;Xiong, Tao;Du, Tonghao;Xiong, Shijin;Xiong, Tao
关键词：Asparagus juice; flavour profiles; LAB fermentation; physicochemical characteristics
-
Two-stage fermentation of corn and soybean meal mixture by Bacillus subtilis and Lactobacillus acidophilus to improve feeding value: optimization, physicochemical property, and microbial community
作者：Du, Tonghao;Xiong, Shijin;Guan, Qianqian;Xie, Mingyong;Xiong, Tao;Du, Tonghao;Xiong, Shijin;Guan, Qianqian;Xie, Mingyong;Xiong, Tao;Wang, Li;Liu, Guangxian;Huang, Jinqing
关键词：Corn and soybean meal mixture; Two-stage fermentation; Microbial community; Physicochemical property; O2PLS analysis
-
Southern China can produce more high-quality rice with less N by green manuring
作者：Gao, Songjuan;Liang, Hai;Li, Shun;Zhou, Guopeng;Chang, Danna;Cao, Weidong;Liang, Hao;Nie, Jun;Liao, Yulin;Lu, Yanhong;Xu, Changxu;Liu, Jia;Wu, Ji;Han, Shang;Wang, Hui;Liu, Chunzeng;Lv, Yuhu;Huang, Yibin;He, Chunmei;Geng, Mingjian;Wang, Jianhong;He, Tieguang;Li, Zhongyi;Rees, Robert M.;Thorup-Kristensen, Kristian
关键词：Greenmanure-rice rotation; Food security; Environmental sustainability; Microbial mechanisms
-
Dynamics of bacterial community, metabolites profile and physicochemical characteristics during solid-state fermentation of soybean meal and corn mixed substrates inoculated with Bacillus pumilus and Limosilactobacillus fermentum
作者：Huang, Jinqing;Liu, Guangxian;Dai, Yuming;Zhang, Yue;Peng, Fei;Xie, Mingyong;Xiong, Tao;Dai, Yuming;Zhang, Yue;Peng, Fei;Xie, Mingyong;Xiong, Tao
关键词：microbiota; high-throughput sequencing; metabolites; nutritional value; two-stage solid-state fermentation
-
Co-60 gamma irradiation induced ovalbumin-glucose glycation and allergenicity reduction revealed by high-resolution mass spectrometry and ELISA assay
作者：Liu, Guang-xian;Tu, Zong-cai;Wang, Hui;Hu, Yueming;Tu, Zong-cai;Yang, Wen-hua;Wang, Hui
关键词：Ovalbumin; Irradiation; Glycation; Allergenicity; Glycated sites
-
Analysis of the Effect of Different Reducing Sugars on Ara h2 Glycation Based on Spectral Technology
作者：Yang, Ping;Wang, Hui;Li, Xue;Liu, Guang-xian
关键词：Glycation; Ara h2; Spectroscopic techniques; Reducing sugar
