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Characterization and Assessment of Sheep-Origin Probiotic Bacillus licheniformis B63 Strain for Potential Use in Intestinal Health and Disease

文献类型： 外文期刊

作者： Hou, Meng 1 ; Lu, Yabin 1 ; Ye, Mengjun 2 ; Li, Na 1 ; Sun, Yawei 1 ; Yao, Gang 1 ; Wang, Jinquan 1 ; Yin, Fangfang 1 ; Peng, Qimin 1 ; Jia, Sheng 1 ; Shi, Rui 1 ; Wang, Xuxiang 1 ;

作者机构： 1.Xinjiang Agr Univ, Coll Vet Med, Urumqi 830052, Peoples R China

2.Jiangxi Acad Agr Sci, Inst Qual & Safety & Stand Agr Produces Res, Nanchang 330200, Peoples R China

关键词： Sheep; Bacillus licheniformis B63; Probiotic; Bacterial diarrhea

期刊名称：PROBIOTICS AND ANTIMICROBIAL PROTEINS （ 影响因子：4.9； 五年影响因子：5.4 ）

ISSN： 1867-1306

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Bacterial diarrhea causes serious losses for the sheep industry. Antibiotic resistance acquired by diarrheal bacteria is still a hurdle in the care of animal health. Thus, it is urgent to develop effective alternatives to antibiotics for controlling bacterial diarrhea. We initially isolated Bacillus spp. from Xinjiang fine wool sheep fecal and determined their properties of hemolysis and tolerance to acid and bile salts to identify potential candidates. Subsequently, we studied the position of a candidate in phylogenetic trees by 16S rRNA sequences and its susceptibility to antibiotics, ability to inhibit diarrheal bacteria, and toxicity, as well as its effects on animal health. Fourteen Bacillus spp. strains were isolated from sheep fecal. We identified the non-hemolysis B63 strain, which exhibited a high tolerance to acid and bile salts. Phylogenetic analysis indicated that the B63 strain is a new strain of Bacillus licheniformis. The B. licheniformis B63 strain was prompt to form spores, susceptible to commonly used antibiotics, and able to inhibit diarrhea-associated bacteria, including Escherichia coli, Staphylococcus aureus, and Salmonella typhi. Animal studies determined that B. licheniformis B63 at 4 x 10(8) CFU/mL was non-toxic to mice and SD rats. Supplement with B. licheniformis B63 promoted the body weight gain of mice, reduced the inflammatory interleukin 6, and increased the jejunum villus height of SD rats. The newly isolated, non-hemolysis, spore-forming B. licheniformis B63 strain should be considered an optimal strain for the development of an effective probiotic supplement to control diarrheal diseases and promote the health of sheep and other animals.

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