Tissue residue distribution and withdrawal time estimation of trimethoprim and sulfachloropyridazine in Yugan black-bone fowl (Gallus gallus domesticus Brisson)
文献类型： 外文期刊
作者： Zhao, Lin 1 ; Zhang, Dawen 2 ; Lan, Jing 1 ; Sun, Xiangdong 1 ; Zhang, Yun 3 ; Wang, Bing 1 ; Ni, Bei 1 ; Wu, Shuang 1 ; Zhang, Ruiying 1 ; Liao, Hui 1 ;
作者机构： 1.Heilongjiang Acad Agr Sci, Qual & Safety Inst Agr Prod, Harbin 150086, Peoples R China
2.Jiangxi Acad Agr Sci, Inst Qual Safety & Stand Agr Prod, Nanchang 330200, Peoples R China
3.Heilongjiang East Univ, Coll Food Engn, Harbin, Peoples R China
关键词： Trimethoprim; sulfachloropyridazine; Yugan black-bone fowl; tissue residue; Withdrawal time; >
期刊名称：FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT （ 影响因子：2.9； 五年影响因子：3.2 ）
ISSN： 1944-0049
年卷期： 2023 年 40 卷 8 期
页码：
收录情况： SCI
摘要： Black-bone fowl are different from ordinary broilers in appearance and are considered to have rich nutritional properties. However, the metabolism of therapeutic drugs in black-bone fowl remains unclear. This study aimed to determine the tissue residue depletion kinetics of trimethoprim and sulfachloropyridazine in Yugan black-bone fowl, after daily oral administrations for 5 days at 4 mg/kg bw/day trimethoprim and 20 mg/kg bw/day sulfachloropyridazine, and to calculate the withdrawal times. After consecutive oral administrations, the tissues (liver, kidney, muscle and skin/fat) were collected at each of the following time points (0.16, 1, 3, 5, 7, 9, 20, 30 and 40 days). A newly-devised LC-MS/MS method was used to analyse the concentrations of trimethoprim and sulfachlorpyridazine in target tissues. The results showed that sulfachloropyridazine was rapidly metabolised in broilers, and there was no residue in all tissues 3 days post-administration. The concentration of trimethoprim in black-bone fowl skin/fat is the highest, and its metabolism rate is low. After 40 days, the concentration of trimethoprim in skin/fat is still as high as 140.1 & PLUSMN; 58.0 & mu;g/kg, exceeding the maximum residue limit. In order to protect consumers' health, it is suggested that the withdrawal time of TMP in Yugan black-bone fowl is 69 days.
- 相关文献
作者其他论文 更多>>
-
Residue Depletion and Withdrawal Interval Estimations of Sulfamonomethoxine or Doxycycline Residues in Chinese Taihe Black-Bone Silky Fowls
作者：Ye, Mengjun;Yuan, Lijuan;Liao, Qiegen;Xiang, Jianjun;Zhang, Li;Ai, Qiushuang;Qiu, Suyan;Dong, Yifan;Yu, Xiren;Zhang, Dawen;Ye, Mengjun;Yuan, Lijuan;Liao, Qiegen;Xiang, Jianjun;Zhang, Li;Ai, Qiushuang;Qiu, Suyan;Dong, Yifan;Yu, Xiren;Zhang, Dawen;Ye, Mengjun;Yuan, Lijuan;Liao, Qiegen;Xiang, Jianjun;Zhang, Li;Ai, Qiushuang;Qiu, Suyan;Dong, Yifan;Yu, Xiren;Zhang, Dawen
关键词：sulfamonomethoxine; doxycycline; Taihe black-bone silky fowl; residue; withdrawal time
-
Residue depletion and withdrawal time estimation of tilmicosin in black-bone silky fowls after administration via drinking water
作者：Zhang, Li;Yuan, Lijuan;Ye, Mengjun;Xiang, Jianjun;Dong, Yifan;Liao, Qiegen;Qiu, Suyan;Zhang, Dawen;Yu, Xiren;Zhang, Li;Yuan, Lijuan;Ye, Mengjun;Xiang, Jianjun;Dong, Yifan;Liao, Qiegen;Qiu, Suyan;Zhang, Dawen;Yu, Xiren;Zhang, Li;Yuan, Lijuan;Ye, Mengjun;Xiang, Jianjun;Dong, Yifan;Liao, Qiegen;Qiu, Suyan;Zhang, Dawen;Yu, Xiren
关键词：Tilmicosin; Taihe black-bone silky fowl; residue; withdrawal time
-
Sensitive Electrochemical Immunosensor for Procymidone Detection Based on a Supramolecular Amplification Strategy
作者：Ai, Qiushuang;Yu, Xiren;Dong, Yifan;Zhang, Li;Liang, Jingtian;Zhang, Dawen;Qiu, Suyan
关键词：
-
Strict relationship between phenotypic and plasmid-associated genotypic of multidrug-resistant Escherichia coli isolated from Taihe Black-Boned Silky Fowl farms
作者：Zhang, Li;Ye, Mengjun;Dong, Yifan;Yuan, Lijuan;Xiang, Jianjun;Yu, Xiren;Liao, Qiegen;Ai, Qiushuang;Qiu, Suyan;Zhang, Dawen;Zhang, Li;Ye, Mengjun;Dong, Yifan;Yuan, Lijuan;Xiang, Jianjun;Yu, Xiren;Liao, Qiegen;Ai, Qiushuang;Qiu, Suyan;Zhang, Dawen;Zhang, Li;Ye, Mengjun;Dong, Yifan;Yuan, Lijuan;Xiang, Jianjun;Yu, Xiren;Liao, Qiegen;Ai, Qiushuang;Qiu, Suyan;Zhang, Dawen
关键词：Escherichia coli; Multidrug resistant; ARGs; Plasmid; Taihe black-boned silky fowl
-
Highly selective localized surface plasmon resonance sensor for selenium diagnosis in selenium-rich soybeans
作者：Qiu, Suyan;Dong, Yifan;Yu, Xiren;Ai, Qiushuang;Yuan, Lijuan;Zhang, Li;Zhang, Dawen
关键词：Selenium detection; Laterals etching; Gold nanorods; Soybean samples; Selenium-rich crops
-
Evaluation of lake eutrophication under different hydrological connectivity conditions
作者：Liu, Jutao;Wen, Chunyun;Hu, Fang;Liu, Xinyuan;Liu, Jutao;Wen, Chunyun;Hu, Fang;Liu, Xinyuan;Zhang, Dawen
关键词：Water connectivity; eutrophication evaluation; Poyang Lake region; cyanobacteria bloom; human activity
-
Response of the microbial community structure to the environmental factors during the extreme flood season in Poyang Lake, the largest freshwater lake in China
作者：Zhang, Li;Yuan, Lijuan;Xiang, Jianjun;Liao, Qiegen;Zhang, Dawen;Liu, Jutao
关键词：Poyang Lake; bacterial diversity; extreme flood season; environmental factors; microbial community
