Tissue residue distribution and withdrawal time estimation of trimethoprim and sulfachloropyridazine in Yugan black-bone fowl (Gallus gallus domesticus Brisson)
文献类型: 外文期刊
作者: Zhao, Lin 1 ; Zhang, Dawen 2 ; Lan, Jing 1 ; Sun, Xiangdong 1 ; Zhang, Yun 3 ; Wang, Bing 1 ; Ni, Bei 1 ; Wu, Shuang 1 ; Zhang, Ruiying 1 ; Liao, Hui 1 ;
作者机构: 1.Heilongjiang Acad Agr Sci, Qual & Safety Inst Agr Prod, Harbin 150086, Peoples R China
2.Jiangxi Acad Agr Sci, Inst Qual Safety & Stand Agr Prod, Nanchang 330200, Peoples R China
3.Heilongjiang East Univ, Coll Food Engn, Harbin, Peoples R China
关键词: Trimethoprim; sulfachloropyridazine; Yugan black-bone fowl; tissue residue; Withdrawal time; >
期刊名称:FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT ( 影响因子:2.9; 五年影响因子:3.2 )
ISSN: 1944-0049
年卷期: 2023 年 40 卷 8 期
页码:
收录情况: SCI
摘要: Black-bone fowl are different from ordinary broilers in appearance and are considered to have rich nutritional properties. However, the metabolism of therapeutic drugs in black-bone fowl remains unclear. This study aimed to determine the tissue residue depletion kinetics of trimethoprim and sulfachloropyridazine in Yugan black-bone fowl, after daily oral administrations for 5 days at 4 mg/kg bw/day trimethoprim and 20 mg/kg bw/day sulfachloropyridazine, and to calculate the withdrawal times. After consecutive oral administrations, the tissues (liver, kidney, muscle and skin/fat) were collected at each of the following time points (0.16, 1, 3, 5, 7, 9, 20, 30 and 40 days). A newly-devised LC-MS/MS method was used to analyse the concentrations of trimethoprim and sulfachlorpyridazine in target tissues. The results showed that sulfachloropyridazine was rapidly metabolised in broilers, and there was no residue in all tissues 3 days post-administration. The concentration of trimethoprim in black-bone fowl skin/fat is the highest, and its metabolism rate is low. After 40 days, the concentration of trimethoprim in skin/fat is still as high as 140.1 & PLUSMN; 58.0 & mu;g/kg, exceeding the maximum residue limit. In order to protect consumers' health, it is suggested that the withdrawal time of TMP in Yugan black-bone fowl is 69 days.
- 相关文献
作者其他论文 更多>>
-
Sensitive detection of cadmium ions based on a quantum-dot-mediated fluorescent visualization sensor
作者:Ai, Qiushuang;Dong, Yifan;Yu, Xiren;Zhang, Dawen;Qiu, Suyan;Wei, Peiling
关键词:
-
Pharmacokinetics, withdrawal time, and dietary risk assessment of enrofloxacin and its metabolite ciprofloxacin, and sulfachloropyridazine-trimethoprim in Taihe black-boned silky fowls
作者:Yuan, Lijuan;Zhang, Li;Xiang, Jianjun;Liao, Qiegen;Luo, Linguang;Zhang, Dawen;Wu, Huizhen;Wang, Jianmei;Zhou, Min;Qian, Mingrong
关键词:antibiotics; dietary risk assessment; pharmacokinetics; Taihe black-boned silky fowl; withdrawal time
-
Pathological and biochemical characterizations of microcystin-LR-induced liver and kidney damage in chickens after acute exposure
作者:Zhang, Dawen;Yuan, Lijuan;Zhang, Li;Liao, Qiegen;Xiang, Jianjun;Luo, Linguang;Qiu, Tong;Xiong, Xiaohui
关键词:Pathological changes; MC-LR; Biochemical characterizations; Liver; Kidney; Chicken
-
Evaluation of the underestimation of citrinin content in Hongqu using hydrolysis treatments and UPLC-FLD
作者:Hou, Yaqi;Liu, Jiao;Peng, Xitian;Zhou, Youxiang;Hou, Yaqi;Shao, Yanchun;Chen, Fusheng;Liu, Jiao;Peng, Xitian;Zhou, Youxiang;Liu, Jiao;Peng, Xitian;Zhang, Dawen;Hu, Lifang;Zhou, Youxiang;Zhang, Dawen;Hu, Lifang
关键词:Citrinin; Modified citrinin; Hongqu; Acid hydrolysis-UPLC-FLD; Method optimization
-
Triazole-stabilized fluorescence sensor for highly selective detection of copper in tea and animal feed
作者:Qiu, Suyan;Wei, Yihua;Tu, Tianhua;Xiang, Jianjun;Zhang, Dawen;Chen, Qinglong;Luo, Linguang;Lin, Zhenyu
关键词:Fluorescence sensor; Tris-(benzyltriazolylmethyl)amine; Copper detection; High reproducibility; Tea; Chicken feed
-
DNA template-mediated click chemistry-based portable signal-on sensor for ochratoxin A detection
作者:Qiu, Suyan;Yuan, Lijuan;Wei, Yihua;Zhang, Dawen;Chen, Qinglong;Luo, Linguang;Lin, Zhenyu
关键词:DNA template-mediated click chemistry; Personal glucose meter; Ochratoxin A; Copper(I) catalyzed azide-alkyne cycloaddition; Magnetic beads
-
Seasonal and spatial variations of microcystins in Poyang Lake, the largest freshwater lake in China
作者:Zhang, Li;Zhang, Dawen;Luo, Linguang;Liao, Qiegen;Yuan, Lijuan;Liu, Jutao;Wu, Naicheng
关键词:Cyanobacteria; Microcystins; Seasonal variation; Spatial distribution; Poyang Lake