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Regulatory effects of tea polysaccharides on hepatic inflammation, gut microbiota dysbiosis, and serum metabolomic signatures in beef cattle under heat stress

文献类型： 外文期刊

作者： Li, Fan 1 ; Xu, Jun 1 ; Xie, Min 3 ; Fei, Dan 3 ; Zhou, Yaomin 3 ; Li, Xiong 4 ; Guang, Yelan 3 ; Gong, Lihui 3 ; Hu, Lizhen 1 ; Feng, Fan 1 ;

作者机构： 1.Jiangxi Acad Agr Sci, Inst Anim Husb & Vet Sci, Nanchang, Peoples R China

2.Jiangxi Prov Key Lab Anim Green & Hlth Breeding, Nanchang, Peoples R China

3.Jiangxi Acad Agr Sci, Inst Qual Safety & Stand Agr Prod, Nanchang, Peoples R China

4.Pingxiang Ctr Agr Sci & Technol Res, Pingxiang, Peoples R China

关键词： tea polysaccharides; inflammation; long-chain fatty acids; gut micobiota; liver

期刊名称：FRONTIERS IN PHYSIOLOGY （ 影响因子：3.4； 五年影响因子：4.0 ）

ISSN：

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Background Long-term heat stress (HS) severely restricts the growth performance of beef cattle and causes various health problems. The gut microbiota plays a crucial role in HS-associated inflammation and immune stress involving lymphocyte function. This study investigated the effects of dietary tea polysaccharide (TPS), a natural acidic glycoprotein, on HS-induced anorexia, inflammation, and gut microbiota dysbiosis in Simmental beef cattle.Methods The cattle were divided into two groups, receiving either normal chow or normal chow plus TPS (8 g/kg, 0.8%). Transcriptome sequencing analysis was used to analysis the differential signaling pathway of liver tissue. 16S rDNA sequencing was performed to analysis gut microbiota of beef cattle. Serum metabolite components were detected by untargeted metabolomics analysis.Results Hepatic transcriptomics analysis revealed that differentially expressed genes in TPS-fed cattle were primarily enriched in immune processes and lymphocyte activation. TPS administration significantly reduced the expression of the TLR4/NF-kappa B inflammatory signaling pathway, alleviating HS-induced hepatic inflammation. Gut microbiota analysis revealed that TPS improved intestinal homeostasis in HS-affected cattle by increasing bacterial diversity and increasing the relative abundances of Akkermansia and Alistipes while decreasing the Firmicutes-to-Bacteroidetes ratio and the abundance of Agathobacter. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis indicated that TPS significantly increased the levels of long-chain fatty acids, including stearic acid, linolenic acid, arachidonic acid, and adrenic acid, in the serum of cattle.Conclusion These findings suggest that long-term consumption of tea polysaccharides can ameliorate heat stress-induced hepatic inflammation and gut microbiota dysbiosis in beef cattle, suggesting a possible liver-gut axis mechanism to mitigate heat stress.

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