Synthesis of new pyrido[1,2-α] pyrimidinone derivatives and investigation of their insecticidal activity
文献类型： 外文期刊
作者： Liu, Haohong 1 ; Zheng, Keyan 2 ; Fang, Qingwen 1 ; Shi, Yunlian 3 ; Xie, Ziyin 1 ; Wang, Jie 1 ; Nie, Xuliang 1 ; Shi, Xugen 3 ; Cui, Ruqiang 3 ; Sun, Gang 1 ; Peng, Dayong 1 ;
作者机构： 1.Jiangxi Agr Univ, Key Lab Chem Utilizat Plant Resources Nanchang, East China Woody Fragrance & Flavor Engn Res Ctr, Coll Chem & Mat,Natl Forestry & Grassland Adm,Jian, Nanchang 330045, Peoples R China
2.Jiangxi Agr Univ, Coll Biosci & Bioengn, Lab Nat Med & Microbiol Drug, Nanchang 330045, Peoples R China
3.Jiangxi Agr Univ, Coll Agron, Nanchang 330045, Peoples R China
4.Jiangxi Acad Agr Sci, Inst Soil Fertilizer & Resource Environm, Jiangxi Prov Key Lab Agr Nonpoint Source Pollut Co, Nanchang 330200, Peoples R China
关键词： Mesoionic; Pyrido [1; 2-alpha] pyrimidinone; Synthesis; Biological activity; Nicotinic acetylcholine receptors
期刊名称：JOURNAL OF MOLECULAR STRUCTURE （ 影响因子：4.7； 五年影响因子：4.0 ）
ISSN： 0022-2860
年卷期： 2025 年 1333 卷
页码：
收录情况： SCI
摘要： Pyrido [1,2-alpha] pyrimidinone represents a unique class of mesoionic heterocyclic compounds with a broad spectrum of functions. Notably, these compounds exhibit significant biological activity, including antibacterial, anti-cancer, insecticidal, and herbicidal properties. Their structure has been widely utilized in various chemical modifications. This study, guided by the principle of structural splicing, focused on modifying the benzene ring, pyrido ring, and side chain of Triflumezopyrim. Through the ring-forming reactions involving benzyl and ester compounds, a series of pyrido [1,2-alpha] pyrimidinone derivatives were synthesized. The research revealed that several of these compounds demonstrated high insecticidal activity against aphids. Molecular docking results indicated that compounds could act on nicotinic acetylcholine receptors. These findings support the potential application of pyrido [1,2-alpha] pyrimidinone compounds as novel insecticides.
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