Danthron ameliorates obesity and MAFLD through activating the interplay between PPAR?/RXR? heterodimer and adiponectin receptor 2
文献类型： 外文期刊
作者： Ma, Chuanrui 1 ; Wang, Zhongyan 8 ; Xia, Ronglin 5 ; Wei, Lingling 9 ; Zhang, Chao 1 ; Zhang, Jing 1 ; Zhao, Linna 1 ; Wu 1 ;
作者机构： 1.Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China
2.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Endocrinol, Shenzhen, Peoples R China
3.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou, Peoples R China
4.Tianjin Key Lab Translat Res TCM Prescript & Synd, Tianjin, Peoples R China
5.Tianjin Univ Tradit Chinese Med, State Key Lab Modern Chinese Med, Tianjin, Peoples R China
6.Peking Union Med Coll & Chinese Acad Med Sci, Natl Hlth Commiss, Peking Union Med Coll Hosp, Dept Endocrinol,Key Lab Endocrinol, Beijing, Peoples R China
7.Tianjin Hosp, Tianjin, Peoples R China
8.Chinese Acad Med Sci & Peking Union Med Coll, Inst Radiat Med, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin, Peoples R China
9.Jiangxi Acad Agr Sci, Inst Agr Econ & Informat, Nanchang, Jiangxi, Peoples R China
关键词： Danthron; Obesity; Hepatic steatosis; AdipoR2; AMPK?; PPAR?
期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：4.545； 五年影响因子：4.392 ）
ISSN： 0753-3322
年卷期： 2021 年 137 卷
页码：
收录情况： SCI
摘要： Obesity and associated metabolic associated fatty liver diseases (MAFLD) are strongly associated with dysfunction of glucose and lipid metabolism. AMPK? and PPAR? are key regulators in the lipid and glucose homeostasis, indicating that novel agents to activate them are promising therapeutic approaches for metabolic syndrome. Noticeably, as a natural anthraquinone derivative extracted from rhubarb , danthron can activate AMPK? in vitro. However, the protective effect of danthron on obesity and associated MAFLD in vivo, as well as the underlying mechanism remains unknown. In this study, obesity and associated MAFLD was induced in C57BL/6J mice by high fat diet (HFD), which were subjected to evaluations on the parameters of systematic metabolism. Simultaneously, the molecular mechanism of danthron on lipid metabolism was investigated in 3T3 L1-derived adipocytes and HepG2 cells in vitro. In vivo , danthron significantly attenuated the obesity and MAFLD by enhancing hepatic fatty acid oxidation, decreasing lipid synthesis, and promoting mitochondrial homeostasis. Mechanistically, danthron significantly promoted combination of RXR? and PPAR?, enhanced the binding of RXR?/PPAR? heterodimer to the promoter of adiponectin receptor 2 (AdipoR2), by which activating the AMPK? and PPAR? pathway. Moreover, PPAR? and AdipoR2 can interplay in a loop style. Collectively, this study demonstrates that danthron can substantially ameliorate obesity and associated hepatic steatosis via AdipoR2mediated dual PPAR?/AMPK? activation, which suggests that danthron might be a novel therapeutic approach for inhibition of obesity and hepatic steatosis.
- 相关文献
作者其他论文 更多>>
-
Lost genome segments associate with trait diversity during rice domestication
作者：Zheng, Xiaoming;Li, Fei;Lou, Danjing;Ge, Jinyue;Fan, Weiya;Han, Zhenyun;Qiao, Weihua;Fang, Wei;Yang, Qingwen;Zheng, Xiaoming;Kim, Sung Ryul;Kohli, Ajay;Ye, Guoyou;Zheng, Xiaoming;Wen, Siyu;Zhong, Limei;Pang, Hongbo;Wang, Tianyi;Pan, Xiaowu;Zhu, Yebao;Wang, Jilin;Tang, Cuifeng;Wang, Xinhua;Zhang, Jing;Zhang, Jing;Xu, Zhijian;Ye, Guoyou;Olsen, Kenneth M.
关键词：Structure variation; Oryza; Domestication; Phenotype; Association
-
Pollution characteristics of livestock faeces and the key driver of the spread of antibiotic resistance genes
作者：Yue, Zhengfu;Zhang, Jing;Zhou, Zhigao;Ding, Changfeng;Wang, Xingxiang;Ding, Changfeng;Wang, Xingxiang;Yue, Zhengfu;Zhang, Jing;Ding, Changfeng;Wang, Xingxiang;Wan, Liping;Liu, Jia;Chen, Liumeng
关键词：Horizontal transfer; Potential hosts; Structural equation modelling; Sulphonamides; Vertical transfer
-
Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPAR gamma
作者：Xiang, Jiaqing;Yang, Guangyan;Wu, Han;Jiang, Lingyun;Liang, Zhen;Kang, Lin;Yang, Shu;Ma, Chuanrui;Ma, Chuanrui;Wei, Lingling;Wu, Han;Zhang, Wei;Tao, Xiuhua;Yang, Shu
关键词：hepatocytes; intrahepatic cholestasis; macrophage; PPARγ tectorigenin
-
Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPAR alpha
作者：Yang, Shu;Qu, Jingtian;Xu, Shixin;Mao, Jingyuan;Fan, Guanwei;Ma, Chuanrui;Yang, Shu;Liu, Lipei;Li, Qi;Feng, Ke;Zhang, Wei;Fan, Guanwei;Ma, Chuanrui;Chen, Yuanli;Wei, Lingling;Fan, Guanwei;Xia, Ronglin;Yu, Miao;Zhang, Wenwen
关键词：Formononetin; SIRT1; PPAR alpha; Hepatic cholestasis
-
Nitrogen Recovery and Transport Efficiency of Winter Rapeseed and Residual Nitrogen Effect on Subsequent Sesame using N-15 Labelling Technique
作者：Wang, Ruiqing;Zhang, Jing;Luo, Tao;Khan, Mohammad Nauman;Hu, Liyong;Wang, Ruiqing;Wei, Lingen
关键词：N-15 Recovery efficiency;N-15 Transport efficiency;Cropping patterns;Residual N effect;Sesame;Winter rapeseed
-
Production of anti-fungal volatiles by non-pathogenic Fusarium oxysporum and its efficacy in suppression of Verticillium wilt of cotton
作者：Zhang, Qinghua;Yang, Long;Zhang, Jing;Wu, Mingde;Jiang, Daohong;Li, Guoqing;Zhang, Qinghua;Yang, Long;Zhang, Jing;Wu, Mingde;Jiang, Daohong;Li, Guoqing;Zhang, Qinghua;Chen, Weidong
关键词：Fusarium oxysporum CanR-46;Volatile organic compounds;Verticillium dahliae;Biological control;Fumigation
