文献类型： 外文期刊

作者： Zhang, Qingling ¹ ; Wang, Jubin ¹ ; Li, Yuanyuan ¹ ; Tung, Jeffrey ⁵ ; Deng, Yingtian ¹ ; Baker, Barbara ⁵ ; Dinesh-Kumar, Savithramma P. ² ; Li, Feng ¹ ;

作者机构： 1.Huazhong Agr Univ, Coll Hort & Forestry Sci, Natl Key Lab Germplasm Innovat & Utilizat Crops, Wuhan 430070, Peoples R China

2.Univ Calif Davis, Dept Plant Biol, Davis, CA 95616 USA

3.Jiangxi Acad Agr Sci, Inst Vegetables & Flowers, Nanchang 330200, Peoples R China

4.Jiangxi Acad Sci, Inst Biol Resources, Key Lab Hort Plant Genet & Improvement Jiangxi Pro, Nanchang 330299, Peoples R China

5.Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94710 USA

6.Hubei Hongshan Lab, Wuhan 430070, Peoples R China

期刊名称：PLANT PHYSIOLOGY （ 影响因子：7.4； 五年影响因子：8.7 ）

ISSN： 0032-0889

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Plant innate immunity mediated by the nucleotide-binding leucine-rich repeat (NLR) class of immune receptors plays an important role in defense against various pathogens. Although key biochemical events involving NLR activation and signaling have been recently uncovered, we know very little about the transcriptional regulation of NLRs and their downstream signaling components. Here, we show that the Toll-Interleukin 1 receptor homology domain containing NLR (TNL) gene N (Necrosis), which confers resistance to Tobacco mosaic virus, is transcriptionally induced upon immune activation. We identified two conserved transcription factors, N required C3H zinc finger 1 (NRZ1) and N required MYB-like transcription factor 1 (NRM1), that activate N in an immune responsive manner. Genetic analyses indicated that NRZ1 and NRM1 positively regulate coiled-coil domain-containing NLR- and TNL-mediated immunity and function independently of the signaling component Enhanced Disease Susceptibility 1. Furthermore, NRZ1 functions upstream of NRM1 in cell death signaling, and their gene overexpression induces ectopic cell death and expression of NLR signaling components. Our findings uncovered a conserved transcriptional regulatory network that is central to NLR-mediated cell death and immune signaling in plants. Two conserved transcription factors constitute a transcriptional amplification loop that plays an essential role in immunity by activating expression of the resistance gene Necrosis.