文献类型： 外文期刊
作者： Zhang, Long 1 ; Xiao, Haihong 1 ; Huang, Jian 1 ; Ouyang, Linghua 1 ; Li, Siming 1 ; Tang, Yanqiang 1 ;
作者机构： 1.Jiangxi Acad Agr Sci, Nanchang 330200, Jiangxi, Peoples R China
2.China West Normal Univ, Minist Educ, Key Lab Southwest China Wildlife Resources Conser, Nanchong 637009, Sichuan, Peoples R China
关键词： Defensin; Goat; Intestine; Genome identification; Real-time PCR
期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）
ISSN： 0378-1119
年卷期： 2021 年 801 卷
页码：
收录情况： SCI
摘要： Defensins represent a family of cysteine-rich peptides that have broad-spectrum antimicrobial activities and serve as a typical kind of effector molecule in the immunity. Ruminant species have a large number of beta-defensins in the absence of alpha- and theta-defensins. It is well-known that the genomes of sheep and cattle harbor at least 43 and 57 beta-defensin genes, respectively. However, the repertoire of the goat beta-defensin gene family has not been fully elucidated. In this study, we identified a total of 50 beta-defensins from the goat genome, including 48 functional genes and 2 pseudogenes. Cross-species genomic and evolutionary analyses showed that all of the beta-defensins in goat chromosomes 8, 13 and 23 present one-to-one orthologous relationships to their sheep and cattle counterparts, whereas some beta-defensin genes in goat chromosome 27 are goat-specific. Moreover, we observed that some duplicated genes in goat chromosome 27 may be derived from gene copy number variation, and the annotation of sheep and cattle beta-defensins appears to be incomplete in the genome. Importantly, real-time PCR analysis showed that 17 beta-defensins are expressed in the small intestine with abundant cBD1s expression. These findings significant increased our knowledge of ruminant beta-defensin and provided useful information for genetic studies, as well as providing a foundation for future research exploring the role of defensins in the immune response.
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