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Residue depletion and withdrawal time estimation of tilmicosin in black-bone silky fowls after administration via drinking water

文献类型： 外文期刊

作者： Zhang, Li 1 ; Yuan, Lijuan 1 ; Ye, Mengjun 1 ; Xiang, Jianjun 1 ; Dong, Yifan 1 ; Liao, Qiegen 1 ; Qiu, Suyan 1 ; Zhang, Dawen 1 ; Yu, Xiren 1 ;

作者机构： 1.Jiangxi Acad Agr Sci, Inst Qual & Safety & Stand Agr Prod Res, Nanchang, Peoples R China

2.Minist Agr & Rural Affairs Peoples Republ China, Key Lab Qual & Safety Control Poultry Prod, Nanchang, Peoples R China

3.Minist Agr & Rural Affairs Peoples Republ China, Lab Qual & Safety Risk Assessment Livestock & Poul, Nanchang, Peoples R China

关键词： Tilmicosin; Taihe black-bone silky fowl; residue; withdrawal time

期刊名称：FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT （ 影响因子：2.2； 五年影响因子：2.8 ）

ISSN： 1944-0049

年卷期： 2025 年 42 卷 2 期

页码：

收录情况： SCI

摘要： In this study, residue depletion and withdrawal time estimation of tilmicosin were examined in Taihe black-bone silky fowls (TBSFs) after oral administration for three consecutive days at a dose of 75 mg/L in water. The tilmicosin concentrations in liver, kidney, muscle, and skin/fat of TBSFs collected from different time points (0.16, 1, 3, 5, 7, 9, 12, 20, 30, 40 days after last administration) were determined by UPLC-MS/MS. The results indicated that the tilmicosin concentrations in TBSFs tissues varied significantly, and kidney had the highest average concentrations (2604.65 +/- 4625.20 mu g/kg), followed by liver (1125.54 +/- 1479.24 mu g/kg), skin/fat (372.81 +/- 428.33 mu g/kg), and muscle (104.52 +/- 143.95 mu g/kg). Meanwhile, tilmicosin was still detected in all the four studied tissues (liver, kidney, skin/fat, and muscle) of TBSFs at the last time point (40th day after administration), suggesting that tilmicosin in TBSFs depleted slowly. Based on our experiments, the recommended withdrawal time of tilmicosin for TBSFs after oral administration for three consecutive days at a dose of 75 mg/L in water should be 32 days, which is much longer than the duration specified by Chinese regulatory authorities (10 days), and the abundance of melanin in TBSFs might be responsible for this phenomenon. Hence, a special use and withdrawal procedure of veterinary drugs in TBSFs is needed, and it is essential to focus on potential involvement of melanin in tilmicosin accumulation.

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