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Effect of the extract made from Rhizoma Atractylodis Macrocephalae (RAM) on the immune responses of mice to a commercial foot-and-mouth disease vaccine

文献类型： 外文期刊

作者： Qin, Ming 1 ; Liu, Jiewei 2 ; Sakwiwatkul, Kedsirin 3 ; Yan, Han 4 ; Chang, Xiaoyu 4 ; Chi, Shengbo 5 ; Li, Yutao 6 ; Li, Ruili 1 ;

作者机构： 1.Yantai Acad Agr Sci, Inst Anim Sci & Vet Med, Yantai, Shandong, Peoples R China

2.Jiangxi Agr Univ, Coll Anim Sci & Technol, Nanchang, Jiangxi, Peoples R China

3.Mahasarakham Univ, Dept Agr Technol, Fac Technol, Maha Sarakham, Thailand

4.Jiangxi Acad Agr Sci, Inst Qual & Safety & Stand Agr Prod, Nanchang, Jiangxi, Peoples R China

5.Laiyang Agrotech Extens Ctr, Yantai, Shandong, Peoples R China

6.Weifang Acad Agr Sci, Inst Anim Sci, Weifang 261071, Shandong, Peoples R China

关键词： decoction; foot-and-mouth disease; Rhizoma Atractylodis Macrocephalae; vaccine

期刊名称：VETERINARY MEDICINE AND SCIENCE （ 影响因子：1.772； 五年影响因子：1.885 ）

ISSN：

年卷期： 2022 年 8 卷 5 期

页码：

收录情况： SCI

摘要： Objectives: Foot-and-mouth disease (FMD) is an economically important animal disease because of the speed of its transmission. Routine vaccination may not be effective; RAM can be considered as a potential facilitator for this. Present study was designed to evaluate the effects of feeding different treatment of the RAM in different days on the immune responses in mice immunised with FMDV type O vaccine. Material and methods: In experiment 1, 50 ICR mice were randomly divided into five groups with 10 animals in each group, and the basic diet containing 1% Crush of RAM for 1-week ad libitum feeding period, 1% Crush of RAM for 6-week ad libitum feeding period, 1% Decoction of RAM for a 1-week ad libitum feeding period, 1% Decoction of RAM for a 6-week ad libitum feeding period, respectively. Blood samples were collected 2 weeks after boosting for measurement of FMDV-specific IgG level and the IgG subclasses, lymphocyte proliferation as well as production IL-5 and IFN-gamma. In experiment 2, four groups mice were fed basic diet and basic diet containing 5% Decoction of RAM for 2-, 4- and 6-day ad libitum feeding periods, respectively. Then we collected blood samples for detecting IgG and IgG subclasses, splenocytes for lymphocyte proliferation as well as production IL-5 and IFN-gamma, and tissue samples of small intestine for sIgA. Results: The results indicated that 1% Decoction of RAM for a 1-week ad libitum feeding period group and 5% Decoction of RAM for 2-, 4- and 6-day ad libitum feeding period group enhance the FMDV-specific immune responses significantly. Conclusions: Taken together, the results demonstrate that doses and feeding time of RAM are important to affect the immune responses.

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