Effects of vitamin D3 on expression of defensins, Toll-like receptors, and vitamin D receptor in liver, kidney, and spleen of Silky Fowl
文献类型： 外文期刊
作者： Li, S. M. 1 ; Ouyang, L. H. 1 ; Zhou, D. G. 2 ;
作者机构： 1.Jiangxi Acad Agr Sci, Inst Anim Husb & Vet, Nanchang, Peoples R China
2.Sichuan Agr Univ, Coll Anim Sci & Technol, Yaan 625014, Sichuan, Peoples R China
关键词： vitamin D_3;induction;chicken;avian beta-defensins;real-time PCR
期刊名称：CZECH JOURNAL OF ANIMAL SCIENCE （ 影响因子：1.267； 五年影响因子：1.428 ）
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收录情况： SCI
摘要： The expression of avian beta-defensins (AvBDs), Toll-like receptors (TLRs), and vitamin D receptor (VDR) following in vivo vitamin D_3 injection was studied Healthy 90-day Silky Fowls were abdominally injected with vitamin D_3 or untreated. Real-timePCR analyses revealed that injection of vitamin D_3 significantly (P < 0.05) up-regulated the expression of TLRs (TLR2, TLRS), VDR, AvBDs (.AVBD-6, GAL-1), and 24-hydroxylase (CYP24A1) in the tissues (liver, spleen, and kidney) at various times 8-24 h post injection. These results suggest that expression of VDR, AvBDs, and TLRs seems to be induced by vitamin D_3 and it was concluded that the tissues expressing TLRs and VDR respond to vitamin D_3 and in turn upregulate these tissues cellular functions tosynthesize AvBDs. Intraperitoneal injection of vitamin D_3 likely resulted in enhancing the expression of AvBDs, TLRs, and VDR, which provided insight into factors important for the control of the innate immune response in the chickens.
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