Enhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4
文献类型： 外文期刊
作者： Chen, Tingting 1 ; Li, Qingguo 2 ; Ai, Gaoxiang 8 ; Huang, Ziwei 2 ; Liu, Jun 5 ; Zeng, Lingfeng 3 ; Su, Ziren 2 ; Dou, Yaoxing 1 ;
作者机构： 1.Guangzhou Univ Chinese Med, Meizhou Hosp Tradit Chinese Med, Meizhou Hosp, 3 Huanan Ave, Meizhou, Guangdong, Peoples R China
2.Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou, Peoples R China
3.Guangzhou Univ Chinese Med, Coll Clin Med 2, Guangzhou, Peoples R China
4.Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China
5.Guangdong Prov Enginering Technol Res Inst Tradit, Guangdong Second Tradit Chinese Med Hosp, Guangzhou, Peoples R China
6.Guangdong Prov Acad Chinese Med Sci, Bone & Joint Res Team Degenerat & Injury, Guangzhou, Peoples R China
7.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
8.Jiangxi Acad Agr Sci, Inst Anim Husb & Vet Sci, Nanchang, Peoples R China
关键词： Acute liver injury; Oxyberberine; Amorphous solid dispersions; Bioavailability
期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.8； 五年影响因子：4.3 ）
ISSN： 2045-2322
年卷期： 2024 年 14 卷 1 期
页码：
收录情况： SCI
摘要： Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective properties. However, the poor water solubility of OBB hinders its release and absorption thus resulting in low bioavailability. To overcome these drawbacks of OBB, amorphous spray-dried powders (ASDs) of OBB were formulated. The dissolution, characterizations, and pharmacokinetics of OBB-ASDs formulation were investigated, and its hepatoprotective action was disquisitive in the D-GalN/LPS-induced acute liver injury (ALI) mouse model. The characterizations of OBB-ASDs indicated that the crystalline form of OBB active pharmaceutical ingredients (API) was changed into an amorphous form in OBB-ASDs. More importantly, OBB-ASDs showed a higher bioavailability than OBB API. In addition, OBB-ASDs treatment restored abnormal histopathological changes, improved liver functions, and relieved hepatic inflammatory mediators and oxidative stress in ALI mice. The spray drying techniques produced an amorphous form of OBB, which could significantly enhance the bioavailability and exhibit excellent hepatoprotective effects, indicating that the OBB-ASDs can exhibit further potential in hepatoprotective drug delivery systems. Our results provide guidance for improving the bioavailability and pharmacological activities of other compounds, especially insoluble natural compounds. Meanwhile, the successful development of OBB-ASDs could shed new light on the research process of poorly soluble medicine.
- 相关文献
作者其他论文 更多>>
-
Unveiling the sweet culprit: Excessive fructose intake leading to kidney injury through hypoxanthine accumulation
作者：Ai, Gaoxiang;Chen, Xiaolian;Ai, Gaoxiang;Chen, Xiaolian;Ai, Gaoxiang;Tan, Wenwen;Huang, Ziwei;Wu, Xiaoyan;Su, Ziren;Chen, Jiannan;Chen, Xiaolian;Xu, Lieqing;Yu, Qiuxia;Xie, Jianhui;Xie, Jianhui;Dou, Yaoxing;Dou, Yaoxing
关键词：Fructose; Hypoxanthine; Kidney injury; Keap1-Nrf2 signaling pathway; NLRP3 inflammasome
-
Mechanism Analysis of UCP2 During the Oxidative Stress Injury of Intestinal Porcine Epithelial Cell Line-J2
作者：Su, Weide;Xu, Chuanhui;Jiang, Hongping;Song, Wenjing;Xiong, Pingwen;Chen, Jiang;Ai, Gaoxiang;Song, Qiongli;Zou, Zhiheng;Wei, Qipeng;Chen, Xiaolian;Su, Weide;Xu, Chuanhui;Jiang, Hongping;Song, Wenjing;Xiong, Pingwen;Chen, Jiang;Ai, Gaoxiang;Song, Qiongli;Zou, Zhiheng;Wei, Qipeng;Chen, Xiaolian
关键词：UCP2; oxidative stress; porcine intestinal epithelial cells; genipin; apoptosis
-
Effects of Fagopyrum dibotrys rhizoma meal supplementation on productive performance, egg quality, egg nutritional value, and serum biochemical parameters of Shanma laying ducks
作者：Xiong, Pingwen;Yu, Dongyou;Xiong, Pingwen;Ai, Gaoxiang;Chen, Jiang;Song, Wenjing;Su, Weide;Song, Qiongli;Xu, Chuanhui;Zou, Zhiheng;Wei, Qipeng;Chen, Xiaolian;Hu, Lizhen;Xiong, Pingwen;Ai, Gaoxiang;Chen, Jiang;Song, Wenjing;Su, Weide;Song, Qiongli;Xu, Chuanhui;Zou, Zhiheng;Wei, Qipeng;Chen, Xiaolian;Hu, Lizhen
关键词：Fagopyrum dibotrys rhizoma meal; productive performance; egg quality; egg nutritional value; serum biochemical parameters; Shanma laying ducks
-
Influence of a rumen ciliate-derived xylanase on the gut microbiota composition: A potential enzyme for prebiotic applications
作者：Su, Weide;Chen, Xiaolian;Ai, Gaoxiang;Wei, Qipeng;Zou, Zhiheng;Xu, Chuanhui;Chen, Jiang;Xiong, Pingwen;Song, Wenjing;Song, Qiongli;Su, Weide;Chen, Xiaolian;Ai, Gaoxiang;Wei, Qipeng;Zou, Zhiheng;Xu, Chuanhui;Chen, Jiang;Xiong, Pingwen;Song, Wenjing;Song, Qiongli;Luo, Huiying
关键词：Xylanase; Xylo-oligosaccharides; Prebiotics; Gut microbiota
-
Mechanisms of the effects of turpiniae folium extract on growth performance, immunity, antioxidant activity and intestinal barrier function in LPS-challenged broilers
作者：Song, Wenjing;Chen, Jiang;Ai, Gaoxiang;Xiong, Pingwen;Song, Qiongli;Wei, Qipeng;Zou, Zhiheng;Chen, Xiaolian;Song, Wenjing;Chen, Jiang;Ai, Gaoxiang;Xiong, Pingwen;Song, Qiongli;Wei, Qipeng;Zou, Zhiheng;Chen, Xiaolian
关键词：Turpiniae Folium extract; Broiler; Lipopolysaccharides; Immune and antioxidant function; Intestinal barrier
-
Soil organic matter components and sesquioxides integrally regulate aggregate stability and size distribution under erosion and deposition conditions in southern China
作者：Guo, Geng;Kong, Yu;Peng, Xiaoying;Ouyang, Zhen;Lin, Jie;Xu, Yanyin;Niu, Manting;Zeng, Guangruo;Liu, Jun;Zhang, Chen
关键词：Soil aggregate stability; Water erosion; Landscape positions; Soil organic matter fractions; Iron and aluminum oxides
-
Estimation of annual soil CO2 efflux under the erosion and deposition conditions by measuring and modeling its respiration rate in southern China
作者：Guo, Geng;Kuai, Jie;Peng, Xiaoying;Lin, Jie;Li, Xiao;Zhang, Xiang;Xu, Yanyin;Zeng, Guangruo;Liu, Jun;Zhang, Chen;Lin, Jie
关键词：Soil carbon efflux; Soil temperature; Soil moisture; Water erosion; Red soil
