Sensitive and selective nanoplasmonic sensor by functionalized nanoporous gold nanoparticle array chip
文献类型： 外文期刊
作者： Zhao, Fusheng 1 ; Qiu, Suyan 1 ; Li, Jingting 1 ; Shih, Wei-Chuan 1 ;
作者机构： 1.Univ Houston, Dept Elect & Comp Engn, 4800 Calhoun Rd, Houston, TX 77004 USA
2.Univ Houston, Dept Chem, 4800 Calhoun Rd, Houston, TX 77004 USA
3.Univ Houston, Dept Chem Engn, 4800 Calhoun Rd, Houston, TX 77004 USA
4.Univ Houston, Program Mat Sci & Engn, 4800 Calhoun Rd, Houston, TX 77004 USA
5.Jiangxi Acad Agr Sci, Inst Qual & Safety & Stand Agr Product Res, Nanchang 330200, Jiangxi, Peoples R China
关键词： NPG-NP array chip;Guanine-quadruplex (G4);Malachite green
期刊名称：PLASMONICS IN BIOLOGY AND MEDICINE XIV
ISSN： 0277-786X
年卷期： 2017 年 10080 卷
页码：
收录情况： SCI
摘要： Nanoplasmonic sensor has become a recent research focus due to its significant signal enhancement and robust signal transduction measured by various techniques. However, since the native gold surface does not have the capability to selectively bind target biomolecules, high molecular specificity has been a challenge. Nanoporous gold nanoparticle (NPG-NP) array chip showcases large specific surface area and high-density plasmonic field enhancement known as "hot-spots". In this paper, we discuss strategies to enhance molecular specificity by functionalizing NPG-NP with unique bio-recognition elements towards both high sensitivity and specificity. A few examples will be given using existing and novel bio-recognition elements.
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