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Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets

文献类型： 外文期刊

作者： Guo, Qi 1 ; Cai, Xuan 1 ; Xu, Congcong 1 ; Luo, Zhen 1 ; Sheng, Yongshuai 1 ; Bao, Jian 1 ; Chen, Xiaolian 3 ; Xu, Jianxi 1 ;

作者机构： 1.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai, Peoples R China

2.Shanghai Key Lab Vet & Biotechnol, Shanghai, Peoples R China

3.Jiangxi Acad Agr Sci, Inst Anim Husb & Vet Sci, Nanchang, Peoples R China

4.Urban Agr South Minist Agr, Key Lab, Sh

关键词： Antioxidant capacities;inflammatory cytokines;N-acetyl cysteine;weaned;piglets

期刊名称：ITALIAN JOURNAL OF ANIMAL SCIENCE （ 影响因子：2.217； 五年影响因子：2.376 ）

ISSN： 1594-4077

年卷期： 2016 年 15 卷 4 期

页码：

收录情况： SCI

摘要： The present study was conducted to investigate the effects of N-acetylcysteine (NAC) on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets. In total, 15 litters, containing 150 14-day-old piglets, were divided, by litter, into suckling (control), weaning and NAC groups. Thus, there were five litters per group. Compared with the suckling group, the weaning group had increased (p<.05) malondialdehyde (MDA), nitric oxide (NO), hydrogen peroxide (H2O2) and interleukin (IL)-6 contents in their serum and pro-inflammatory cytokine IL-6 and IL-1 beta expression levels in the jejunum, while they had decreased superoxide dismutase (SOD) (p=.055) and glutathione peroxidase (GSH-Px) (p=.057) activities, as well as IL-4 (p<.05) concentrations in their serum and I-kappa B alpha expression (p<.05) in their jejunum. Dietary supplementation with NAC had improved (p<.05) antioxidant status in serum and increased (p<.05) levels of IL-4 but decreased (p<.05) mRNA expression levels and concentrations of IL-6 and IL-1 beta. Meanwhile, the I-kappa B alpha expression level in the jejunum of the NAC-treated group increased (p<.05) compared with the weaning group. In conclusion, weaning resulted in oxidative stress, and dietary supplementation with NAC could increase the antioxidant capacities, while decreasing the jejunal expression of inflammatory cytokines in weaned piglets.

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[1]Effect of N-acetyl cysteine on enterocyte apoptosis and intracellular signalling pathways' response to oxidative stress in weaned piglets. Zhu, Lihui,Cai, Xuan,Guo, Qi,Chen, Xiaolian,Zhu, Suwen,Xu, Jianxiong,Chen, Xiaolian. 2013

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