Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets
文献类型： 外文期刊
作者： Guo, Qi 1 ; Cai, Xuan 1 ; Xu, Congcong 1 ; Luo, Zhen 1 ; Sheng, Yongshuai 1 ; Bao, Jian 1 ; Chen, Xiaolian 3 ; Xu, Jianxi 1 ;
作者机构： 1.Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai, Peoples R China
2.Shanghai Key Lab Vet & Biotechnol, Shanghai, Peoples R China
3.Jiangxi Acad Agr Sci, Inst Anim Husb & Vet Sci, Nanchang, Peoples R China
4.Urban Agr South Minist Agr, Key Lab, Sh
关键词： Antioxidant capacities;inflammatory cytokines;N-acetyl cysteine;weaned;piglets
期刊名称：ITALIAN JOURNAL OF ANIMAL SCIENCE （ 影响因子：2.217； 五年影响因子：2.376 ）
ISSN： 1594-4077
年卷期： 2016 年 15 卷 4 期
页码：
收录情况： SCI
摘要： The present study was conducted to investigate the effects of N-acetylcysteine (NAC) on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets. In total, 15 litters, containing 150 14-day-old piglets, were divided, by litter, into suckling (control), weaning and NAC groups. Thus, there were five litters per group. Compared with the suckling group, the weaning group had increased (p<.05) malondialdehyde (MDA), nitric oxide (NO), hydrogen peroxide (H2O2) and interleukin (IL)-6 contents in their serum and pro-inflammatory cytokine IL-6 and IL-1 beta expression levels in the jejunum, while they had decreased superoxide dismutase (SOD) (p=.055) and glutathione peroxidase (GSH-Px) (p=.057) activities, as well as IL-4 (p<.05) concentrations in their serum and I-kappa B alpha expression (p<.05) in their jejunum. Dietary supplementation with NAC had improved (p<.05) antioxidant status in serum and increased (p<.05) levels of IL-4 but decreased (p<.05) mRNA expression levels and concentrations of IL-6 and IL-1 beta. Meanwhile, the I-kappa B alpha expression level in the jejunum of the NAC-treated group increased (p<.05) compared with the weaning group. In conclusion, weaning resulted in oxidative stress, and dietary supplementation with NAC could increase the antioxidant capacities, while decreasing the jejunal expression of inflammatory cytokines in weaned piglets.
- 相关文献
作者其他论文 更多>>
-
Effects of Fermented Navel Orange Pulp on Growth Performance, Carcass Characteristics, Meat Quality, Meat Nutritional Value, and Serum Biochemical Indicators of Finishing Tibetan Pigs
作者：Xu, Chuanhui;Xiong, Pingwen;Song, Wenjing;Song, Qiongli;Ji, Huayuan;Chen, Xiaolian;Xu, Chuanhui;Zou, Zhiheng;Hu, Yan;Song, Tongxing
关键词：fermented navel orange pulp; growth performance; carcass characteristics; meat quality; meat nutritional value; serum biochemical indicators; finishing Tibetan pigs
-
Characteristics and potential biomarkers of flavor compounds in four Chinese indigenous chicken breeds
作者：Xiong, Xinwei;Ma, Jinge;He, Qin;Wang, Zhangfeng;Li, Longyun;Xu, Jiguo;Rao, Yousheng;Chen, Xiaolian;Xie, Jinfang
关键词：Chinese indigenous chicken; meat flavor; volatile organic compounds; potential biomarkers; breeds
-
Dietary supplementation with honeycomb extracts positively improved egg nutritional and flavor quality, serum antioxidant and immune functions of laying ducks
作者：Chen, Xiaolian;Xiong, Pingwen;Song, Wenjing;Song, Qiongli;Zou, Zhiheng;Huang, Jiangnan;Chen, Jiang;Xu, Chuanhui;Su, Weide;Ai, Gaoxiang;Wei, Qipeng
关键词：honeycomb extracts; laying performance; nutritional and flavor quality; antioxidant function; immune function; laying duck
-
Effect of crossbreeding and sex on slaughter performance and meat quality in Xingguo gray goose based on multiomics data analysis
作者：Huang, Jiangnan;Rao, Linjie;Zhang, Weihong;Chen, Xiaolian;Li, Haiqin;Zhang, Fanfan;Xie, Jinfang;Wei, Qipeng
关键词：crossbreeding; goose; meat quality; metabolomics; transcriptome
-
Effects of traditional Chinese herbal feed supplement on growth performance, immunity, antioxidant levels, and intestinal health in chickens: a study on Ningdu yellow chickens
作者：Song, Wenjing;Zou, Zhiheng;Chen, Xiaolian;Tan, Jia;Liu, Linxiu;Wei, Qipeng;Xiong, Pingwen;Song, Qiongli;Chen, Jiang;Su, Weide;Xu, Chuanhui
关键词：chicken; traditional Chinese prescription; growth performance; immunity and antioxidant; intestinal health
-
Effect of N-acetyl cysteine on enterocyte apoptosis and intracellular signalling pathways' response to oxidative stress in weaned piglets
作者：Zhu, Lihui;Cai, Xuan;Guo, Qi;Chen, Xiaolian;Zhu, Suwen;Xu, Jianxiong;Chen, Xiaolian
关键词：Piglets;Intestinal morphology;N-acetyl-L-cysteine;Apoptosis
-
Pre-protective effect of lipoic acid on injury induced by H2O2 in IPEC-J2 cells
作者：Cai, Xuan;Chen, Xiaolian;Wang, Xiaochun;Xu, Congcong;Guo, Qi;Zhu, Lihui;Zhu, Shuwen;Xu, Jianxiong;Cai, Xuan;Wang, Xiaochun;Xu, Congcong;Guo, Qi;Zhu, Lihui;Zhu, Shuwen;Xu, Jianxiong;Chen, Xiaolian
关键词：Lipoic acid;IPEC-J2;H2O2;Oxidative stress
