Nanoporous Gold Disks Functionalized with Stabilized G-Quadruplex Moieties for Sensing Small Molecules
文献类型： 外文期刊
作者： Qiu, Suyan 1 ; Zhao, Fusheng 1 ; Zenasni, Oussama 1 ; Li, Jingting 1 ; Shih, Wei-Chuan 1 ;
作者机构： 1.Univ Houston, Dept Elect & Comp Engn, 4800 Calhoun Rd, Houston, TX 77204 USA
2.Univ Houston, Dept Biomed Engn, 4800 Calhoun Rd, Houston, TX 77204 USA
3.Univ Houston, Program Mat Sci & Engn, 4800 Calhoun Rd, Houston, TX 77204 USA
4.Univ Houston, Dept Chem, 4800 Calhoun Rd, Houston, TX 77204 USA
5.Jiangxi Acad Agr Sci, Inst Qual & Safety & Stand Agr Prod Res, Nanchang 330200, Jiangxi, Peoples R China
关键词： G-quadruplex moieties;nanoporous gold disks;malachite green;surface enhanced Raman scattering;small molecule sensing
期刊名称：ACS APPLIED MATERIALS & INTERFACES （ 影响因子：9.229； 五年影响因子：9.57 ）
ISSN： 1944-8244
年卷期： 2016 年 8 卷 44 期
页码：
收录情况： SCI
摘要： We report label-free small molecule sensing on nanoporous gold disks functionalized with stabilized Guanine-quadruplex (G4) moieties using surface-enhanced Raman spectroscopy (SERS). By utilizing the unique G4 topological structure, target molecules can be selectively captured onto nanoporous gold (NPG) disk surfaces via pi-pi stacking, and electrostatic attractions. Together with high-density plasmonic "hot spots" of NPG disks, the captured molecules produce a remarkable SERS signal. Our strategy-represents the first example of the detection of foreign molecules conjugated to nondouble helical DNA nanostructures using SERS while providing a new technique for studying the formation and evolution of G4 moieties. The molecular specificity of G4 is known to be controlled by its unit sequence. Without losing generality, we have selected d(GGT)(7)GG sequence for the sensing of malachite green (MG), a known carcinogen frequently abused illegally in aquaculture. The newly developed technique achieved a lowest detectable concentration at an impressive SO pM, two orders of magnitude lower than the European Union (EU) regulatory requirement, with high specificity against potential interferents. To demonstrate the translational potential of this technology, we achieved a lowest detectable concentration of 5.0 nM, meeting the EU regulatory requirement, using a portable probe based detection system.
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