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Nuclease treatment enhanced the ameliorative effect of yeast culture on epidermal mucus, hepatic lipid metabolism, inflammation response and gut microbiota in high-fat diet-fed zebrafish

文献类型： 外文期刊

作者： Zhao, Yajie 1 ; Hao, Qiang 2 ; Zhang, Qingshuang 2 ; Yang, Yalin 4 ; Ran, Chao 4 ; Xu, Qiyou 1 ; Wu, Chenglong 1 ; Liu, Wenshu 5 ; Li, Siming 5 ; Zhang, Zhen 4 ; Zhou, Zhigang 1 ;

作者机构： 1.Huzhou Univ, Coll Life Sci, Huzhou, Peoples R China

2.Chinese Acad Agr Sci, Feed Res Inst, China Norway Joint Lab Fish Gut Microbiota, Beijing, Peoples R China

3.Norwegian Univ Sci & Technol, Inst Biol, Norway China Joint Lab Fish Gut Microbiota, N-7491 Trondheim, Norway

4.Chinese Acad Agr Sci, Feed Res Inst, Key Lab Feed Biotechnol Minist Agr & Rural Affairs, Beijing 100081, Peoples R China

5.Jiangxi Acad Agr Sci, Inst Anim Husb & Vet, Nanchang 330200, Jiangxi, Peoples R China

6.Chinese Acad Agr Sci, Inst Feed Res, Sino Norway Joint Lab Fish Gut Microbiota, Beijing 100081, Peoples R China

关键词： Yeast culture; Nuclease; Lipid metabolism; Inflammation response; Gut microbiota; High-fat diet

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.622； 五年影响因子：4.799 ）

ISSN： 1050-4648

年卷期： 2022 年 131 卷

页码：

收录情况： SCI

摘要： As a functional feed additive, yeast cultures are rich in nucleotides, and adding extra nuclease can significantly increase the content of nucleotides in yeast culture. In this experiment, the effects on growth, epidermal mucus, liver and intestinal health of zebrafish were evaluated by supplementing the yeast culture or nuclease-treated yeast culture with a high-fat diet (HFD). One-month-old zebrafish were fed four diets: normal diet (NORM), HFD, yeast culture diet (YC), and nuclease-treated yeast culture diet (YC (N)) for three weeks. Results showed that the complement 4 activity of the epidermal mucus in YC (N) group was significantly higher than those in HFD and YC groups (P < 0.05). The YC and YC (N) significantly reduced the content of hepatic triglyceride caused by HFD (P < 0.05). Moreover, compared with the YC group, the YC (N) significantly increased the expression of lipolysis genes, such as PPAR alpha, PGC1 alpha, ACOX3 (P < 0.05). Compared with the YC group, the YC (N) group significantly increased the expression of liver pro-inflammatory factors TNF alpha, IL-6, IL-1 beta and anti-inflammatory factors TGF beta, IL-10 (P < 0.05). The diet YC and YC (N) significantly improved the height of the intestinal villus (P < 0.05). Compared with the HFD group, the YC (N) group significantly increased the expression of intestinal pro-inflammatory factors TNF alpha, IL-6 and anti-inflammatory factors TGF beta, IL-10 (P < 0.05). The YC (N) group significantly decreased the abundance of intestinal Proteobacteria and Acinetobacter, and increased the abundance of intestinal Actinobacteria, Mycobacterium and Rhodobacter (P < 0.05). In conclusion, compared with the supplement of yeast culture, nuclease treated yeast culture can further alleviate the adverse effects of HFD on liver and intestinal health, and be used as feed additives for the nutritional and immune regulation of fish.

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