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The role of cysteine conjugation in the detoxification of microcystin-LR in liver of bighead carp (Aristichthys nobilis): a field and laboratory study

文献类型： 外文期刊

作者： Zhang, Dawen 1 ; Yang, Qiang 1 ; Xie, Ping 1 ; Deng, Xuwei 1 ; Chen, Jun 1 ; Dai, Ming 1 ;

作者机构： 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China

2.Jiangxi Acad Agr Sci, Inst Qual & Safety & Stand Agr Prod Res, Key Lab Qual & Safety Agr Prod, Nanchang 330200, Jiangxi, Peoples R China

关键词： Microcystins;MC-LR-Cys;MC-LR-GSH;Bighead carp;Detoxification

期刊名称：ECOTOXICOLOGY （ 影响因子：2.823； 五年影响因子：2.958 ）

ISSN： 0963-9292

年卷期： 2012 年 21 卷 1 期

页码：

收录情况： SCI

摘要： The role of glutathione (GSH) and cysteine (Cys) conjugates in the detoxification of microcystin-LR (MC-LR) in bighead carp (Aristichthys nobilis) was examined under laboratory and field conditions. Wild individuals of bighead carp were collected from 5 eutrophic lakes along the Yangtze River, while in laboratory experiment, bighead carp were injected intraperitoneally with 500 mu g purified MC-LR/kg body weight (bw). Contents of MC-LR and its glutathione (MC-LR-GSH) and cysteine conjugates (MC-LR-Cys) in the liver of bighead carp were determined by liquid chromatography electrospray ionization mass spectrum (LC-ESI-MS). In laboratory experiment, low concentrations of MC-LR-GSH (mean: 0.042 mu g/g dry weight (DW)) were always detectable, and the mean ratio of MC-LR-Cys to MC-LR-GSH was 6.55. While, in field study, relatively high MC-LR-Cys concentration (mean: 0.22 mu g/g DW) was detected, whereas MC-LR-GSH was occasionally detectable, and the average ratio of MC-LR-Cys to MC-LR-GSH was as high as 71.49. A positive correlation was found between MC-LR-Cys concentration in the liver of bighead carp and MC-LR content in seston from the five lakes (r = 0.85). These results suggest that MC-LR-Cys might be much more important than MC-LR-GSH in the detoxification of MC-LR in fish liver, and that cysteine conjugation of MC-LR might be a physiological mechanism for the phytoplanktivorous bighead carp to counteract toxic cyanobacteria.

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[1]Occurrence and spatial distributions of microcystins in Poyang Lake, the largest freshwater lake in China. Zhang, Dawen,Liao, Qiegen,Zhang, Li,Wang, Donggen,Luo, Linguang,Chen, Yuwei,Zhong, Jiayou,Liu, Jutao. 2015

[2]Risk assessment of microcystins in silver carp (Hypophthalmichthys molitrix) from eight eutrophic lakes in China. Zhang, Dawen,Deng, Xuwei,Xie, Ping,Chen, Jun,Guo, Longgen,Zhang, Dawen.

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